Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

[ad_1] Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators. The findings are poised to redirect lupus research and open the door to more precise therapies that avoid broad…

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AZ’s bid for Fasenra approval in COPD falls short

[ad_1] AstraZeneca’s hopes of a big new indication for respiratory drug Fasenra in chronic obstructive pulmonary disease (COPD) have been dashed by a negative phase 3 trial. The RESOLUTE study of IL-5 inhibitor Fasenra (benralizumab) showed some improvement with Fasenra compared to placebo in reducing COPD exacerbations, or attacks, that signal progression of the debilitating…

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