Novo Nordisk Reveals P-III (REDEFINE 1) Trial Data of Cagrilintide for Weight Loss in Obese/Overweight 

Novo Nordisk Reveals P-III (REDEFINE 1) Trial Data of Cagrilintide for Weight Loss in Obese/Overweight 


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  • Novo Nordisk has reported a sub-analysis of P-III (REDEFINE 1) trial assessing cagrilintide monotx. (2.4mg) with lifestyle intervention vs PBO in 3,417 obese/overweight pts with ≥1 obesity-related comorbidities, & without type 2 diabetes
  • Trial showed 11.8% superior weight loss vs 2.3% after 68wks., while 31.6% lost ≥15% of body weight vs 4.7%. However, weight loss was 11.5% vs 3%, with 31% vs 5.2% pts achieving ≥15% weight loss using treatment policy estimand. Data was presented at EASD’25
  • Additionally, cagrilintide will be assessed in P-III (RENEW) trial programme for people with obesity or overweight by Q4’25

Ref: Novo Nordisk Image: Novo Nordisk | Press Release

Related News:- Novo Nordisk Reports STEER Real-World Study Data on Wegovy for Obesity and Cardiovascular Disease

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