MAIA Biotechnology Reports P-II (THIO-101) Trial of Ateganosine Regimen for Advanced NSCLC


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  • MAIA Biotechnology has reported P-II (THIO-101) trial data assessing ateganosine followed by  Libtayo (cemiplimab) in pts with advanced NSCLC who progressed after ≥2 SoC therapy regimens 
  • As of Jun 30, 2025, ateganosine (180mg) showed mPFS of 5.6 vs 2.5mos. & mOS of 17.8mos., plus 2 pts completed 33 cycles across pts of all treatment lines, suggesting potential for extended dosing; data presented at WCLC’25
  • Ateganosine (THIO, 6-thio-dG) is a telomere-targeting agent in development for NSCLC, with the P-II (THIO-101) expansion trial enrolling pts since Jul 2025

Ref: MAIA Biotechnology | Image: MAIA Biotechnology | ⁠Press Release

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