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50 year old with MND:
pH 7.122 severe acidaemia
pCO2 108 severe respiratory acidosis
compensation –
if acute expected HCO3 = 31
if chronic expected HCO3 = 52
actual HCO3 = 38 => acute on chronic respiratory acidosis
pO2 171 – high –??supplemental oxygen
O2 sats 98% within normal limits
unable to calculate A-a gradient because O2 not mentioned
Hb 183 – Polycythaemic – confirms long standing CO2 retention
Normal Na, K, Cl
anion gap 6
Glucose 9.5 – stress response, diabetes, steroids
normal lactate
Interpretation:
50 year old male with MND presents with life threatening acute on chronic respiratory acidosis
Causes – chronic CO2 retention (due to end stage MND, drugs, other eg. COPD) exacerbated by supplemental Oxygen, drugs eg. opiods for pain
Immediate Implications – stop O2, BiPaP, art line (monitor ABG), consider naloxone (if drug induced), ICU consult, avoid intubation (weaning issues)
Vitals – massive sympathetic surge and thorarcic back pain –> consider hypertensive emergency ( eg. aortic dissection)
Further implications – CT Aortogram in unstable patient with respiratory compromise, operative vs conservative management if dissection, management of tachycardia and BP, discussion between family, patient and cardiothoracic surgery regarding prognosis and expected course if diagnosis confirmed, ICU admission.
As it turns out this patient had a negative CT scan and other investigations failed to reveal a cause. Possible autonomic dysfunction which can occur in motor neurone disease.
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