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In cirrhotic upper GI bleeding (UGIB) patients, guidelines recommending routine 5–7 days of prophylactic antibiotics did not lower mortality compared with shorter courses, or no antibiotics, in a contemporary Bayesian meta-analysis.
Source
Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis: A Systematic Review and Bayesian Meta-Analysis. JAMA Intern Med. 2025 Aug 11:e253832. doi: 10.1001/jamainternmed.2025.3832. Epub ahead of print. PMID: 40788637; PMCID: PMC12340683
