What was it? Multicenter, double-blind, sham-controlled randomized clinical trial (PRINCE study) evaluating remote ischemic preconditioning (RIPC) versus sham intervention to reduce myocardial injury in adult patients undergoing major noncardiac surgery. RIPC involved three cycles of 5-minute limb ischemia (via blood pressure cuff inflation to 200 mmHg) followed by 5-minute reperfusion at the start of surgery….
What was it? Multicenter, randomized, open-label trial evaluating the safety and efficacy of intravenous rehydration in children with severe acute malnutrition (SAM) and gastroenteritis, comparing low-volume rehydration (World Health Organization [WHO] standard) with higher-volume rehydration protocols. The Devil in the Details! 272 children analyzed across 4 countries in Africa Three arms: WHO standard (low-volume, 100…
What was it? Multicenter, adaptive, single-blind, randomized controlled trial (NOTACS) evaluating high-flow nasal therapy (HFNT) versus standard oxygen therapy (SOT) in adult patients at high risk of postoperative pulmonary complications (PPCs) following cardiac surgery with cardiopulmonary bypass. The trial aimed to assess clinical and cost-effectiveness over 90 days post-surgery. The Devil in the Details! 850–1280…
What was it? Multicenter, randomized controlled trial evaluating acute normovolemic hemodilution (ANH) versus standard care in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). The Devil in the Details! 200 patients analyzed (100 ANH, 100 control) across 3 academic hospitals in Italy and Russia. ANH involved removing 10-15% of blood volume pre-CPB, replacing it with…
What was it? A multicenter, pragmatic, cluster-randomized, crossover trial evaluating hospital-wide use of lactated Ringer’s solution versus normal saline for intravenous fluid therapy in adult inpatients across multiple Canadian hospitals. Conducted by the Canadian Critical Care Trials Group, the trial aimed to compare the safety and efficacy of these fluids in a real-world setting. The…
Othman AA, Sadek AA, Ahmed EA, Abdelkreem E. Combined Ketamine and Midazolam Versus Midazolam Alone for Initial Treatment of Pediatric Generalized Convulsive Status Epilepticus (Ket-Mid Study): A Randomized Controlled Trial. Pediatr Neurol. 2025 Jun;167:24-32. doi: 10.1016/j.pediatrneurol.2025.03.011. Epub 2025 Mar 22. PMID: [40186980] Source link
What was it? Single-center, prospective, observational study evaluating the clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness (ICU-AW) in patients with cardiogenic shock (CS) requiring mechanical circulatory support (MCS). Conducted at Kyushu University, Japan, the study focused on identifying factors associated with ICU-AW, defined by a Medical Research Council (MRC) score < 48…
What was it? A multicenter, two-arm, pragmatic, stepped-wedge cluster randomized controlled trial (ENCOMPASS) evaluating the Sepsis Transition and Recovery (STAR) program, a navigator-led, telehealth-based intervention, versus usual care, to improve outcomes for sepsis survivors post-hospital discharge. Conducted across eight hospitals in North Carolina, the study used a hybrid type I effectiveness-implementation design to assess clinical…
What was it? Multicenter, randomized, controlled trial (RESCUE-3) evaluating temporary transvenous diaphragm neurostimulation (TTDN) using the Lungpacer Diaphragm Pacing Therapy System versus standard of care (SoC) for weaning from mechanical ventilation in critically ill patients with diaphragm dysfunction. The Devil in the Details! 223 patients across 33 centers in the US, France, and Germany. Patients…
What was it? A multicenter, cluster-randomized, cross-sectional, double cross-over, open-label, registry-embedded, pragmatic clinical trial evaluating the effect of augmented enteral protein delivery (1.2–2.0 g/kg/day) versus usual care (lower protein dose) on clinical outcomes in critically ill adult patients admitted to intensive care units (ICUs) across Australia and New Zealand. The Devil in the Details! 2,092…